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1) Hemorrhoid cream for reducing under-eye circles. Hemorrhoid creams soothe and shrink delicate rectal tissues by constricting blood vessels. Put a little under your eyes, and some dermatologists say it’ll work the same way, de-puffing eye bags and getting rid of dark circles around the thin skin of your under-eye area. That said, this is a home remedy that hinges on whether you can handle the smell, as hemorrhoid cream doesn’t exactly have the most fragrant odor.

2) Maggots to heal a wound. This ancient remedy has experienced a resurgence in modern hospitals in the past decade, according to an article in the March 2009 issue of the Journal of Diabetes Science and Technology. That’s thanks in part to the rise of antibiotic-resistant bacteria finding their way into bed sores, post-surgical wounds, and foot ulcers commonly found in diabetics. How it works: Doctors place creepy, crawly fly larvae onto a patient’s wound. Immediately the squirmy maggots start feeding on bacteria-laden tissue, clearing it out and allowing healthy tissue to grow in.

3) Leeches for dissolving blood clots. It’s another old-school cure that modern docs are bringing back, CBS News reported last year. Leeches are slimy, eel-like critters usually found in lakes, where they attach themselves to a host and feed by leeching blood through your skin. To treat a blood clot or boost blood circulation in an injured body part, MDs might put one of these blood suckers on the skin for 15 or so minutes, where they bust clots and reestablish optimum blood flow. The FDA approved the sale of leeches for medicinal purposes in 2004, so at least docs don’t have to wade through ponds to find them.

4) Horse urine for hot flashes. Short-term hormone-replacement therapy has helped many women deal with the discomfort of menopausal symptoms such as hot flashes. But the hormones in one type of HRT, known by the brand name Premarin, come from a pretty icky source: horse urine, specifically that of a pregnant mare, who produces excess estrogen in her urine.

5) Chia seeds to score nutrients. These are the gritty, unappetizing little seeds that when mixed with water and slathered on a terra cotta figure sprout into a green ‘fro of hair. Now they’re a trendy superfood, with nutritionists touting their high levels of antioxidants, omega-3 fatty acids, and fiber, according to an article in The New York Times. Native to Central and South America, the seeds are finding their way into stir-frys, cereal, juices, even cookies. (Women’s Health)